Metribolone is one of the strongest oral building steroids ever. This substance is a type of trenbolone (trienolone) that goes through c-17 alpha alkylation to enable oral administration.
As a result of this modification, steroids were developed that were more potent than their predecessors, which were not methylated. Its potency is 120-300 times that of methyltestosterone with a large separation between anabolic and androgenic effects.
On a milligram for milligram basis, Methyltrinolon is more potent than any steroid currently on the commercial market, requiring doses as low as 0.5-1 milligram per day to produce strong anabolic effects. Its potential is matched by its relative toxicity, which greatly limits its area of use.
The substance is used for research purposes only.
Metribolone was first described in 1965. It is considered one of the most powerful anabolic drugs on the market. Despite its relatively high potential, Metribolone has a relatively short history of use. In the late 1960s and early 1970s, the drug was used in clinical practice primarily for the treatment of advanced breast cancer. The strong anabolic/androgenic ratio allows the drug to counteract the local effects of estrogen, making it effective in slowing or even regrowth of tumors.
However, the drug remained unpopular for a long time due to the more practical assessment of its toxicity, it was immediately stopped being used in medical practice. In the mid-1970s, animal studies began with methyltrinolone, specifically for the activation of androgen receptors.
The special efficacy of the drug and the stabilization of proteins in the serum make it an excellent receptor binding agent compared to other steroids in vitro. In metabolic resistance, the active metabolites of methyltrinolone did not significantly affect the results of most experiments.
The tissues of the body can readily absorb most steroids, which means that even incubation studies cannot answer the question of the reason for the effectiveness of methyltrinolone, the steroid itself or any of its unknown metabolites. To date, Metribolone has only been used for research purposes.
Metribolone, also known as 17 & alpha; methyltrenbolone, also 17 & alpha-methyl-b 9,11-19-nortestosterone or 17a-methylestr-4,9,11-trien-17β-ol-3-one, is a synthetic steroid estrana and 17α-alkylated derivative of nandrolone (19). – nortestosterone).
It is a C17a methylated derivative of trenbolone (δ9,11-19-nortestosterone) and C9- and C11-dehydrogenated (δ9,11) analog of normethandrone (17α-methyl-19-nortestosterone).
Other close relatives and those derived from metribolone include mibolerone (7α, 17α-dimethyl-19-nortestosterone) and dimethyltrienolone (RU-2420; 7α, 17α-dimethyl-δ 9,11-19-nortestosterone).
In addition to AAS, trimethyltrienolone (R2956; 2α, 2β, 17a-trimethyl-b 9,11-19-nortestosterone), a powerful antiandrogen, was derived from metribolone.